This HTML5 document contains 204 embedded RDF statements represented using HTML+Microdata notation.

The embedded RDF content will be recognized by any processor of HTML5 Microdata.

Subject Item

dbpedia-es:Tirosin_hidroxilasa

dbo:wikiPageRedirects

dbpedia-es:Tirosina_hidroxilasa

Subject Item

dbpedia-es:Tirosín_hidroxilasa

dbo:wikiPageRedirects

dbpedia-es:Tirosina_hidroxilasa

Subject Item

dbr:Tyrosine_hydroxylase

owl:sameAs

dbpedia-es:Tirosina_hidroxilasa

Subject Item

dbpedia-es:Tirosina_hidroxilasa

rdf:type

dbo:Biomolecule wikidata:Q8054 wikidata:Q206229 owl:Thing dbo:Protein

rdfs:label

Tirosina hidroxilasa

rdfs:comment

La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​

owl:sameAs

n6:0cwbks

dct:subject

category-es:Hidroxilasas category-es:Neurotransmisores category-es:Oxigenasas

foaf:isPrimaryTopicOf

wikipedia-es:Tirosina_hidroxilasa

prop-es:altsymbols

DYT14; DYT5b; TYH

prop-es:autor

Zhou QY, Quaife CJ, Palmiter RD Kobayashi K, Kaneda N, Ichinose H, et al. Knappskog PM, Flatmark T, Mallet J, et al. Le Bourdellès B, Boularand S, Boni C, et al. Meloni R, Biguet NF, Mallet J Lüdecke B, Bartholomé K Haycock JW, Ahn NG, Cobb MH, Krebs EG Craig SP, Buckle VJ, Lamouroux A, et al. Lüdecke B, Dworniczak B, Bartholomé K Kaneda N, Kobayashi K, Ichinose H, et al. Ginns EI, Rehavi M, Martin BM, et al. Grima B, Lamouroux A, Boni C, et al. Haycock JW O'Malley KL, Anhalt MJ, Martin BM, et al. Joh TH, Park DH, Reis DJ Masserano JM, Weiner N Vulliet PR, Woodgett JR, Cohen P Coker GT, Vinnedge L, O'Malley KL

prop-es:año

1979 1983 2002 1986 1987 1984 1990 1988 1989 1995 1992 1996

prop-es:banda

155

prop-es:brazo

p

prop-es:chembl

1969

prop-es:cromosoma

11

prop-es:doi

101111 101093 101016 101021 101007 101038 101385 101159 101073

prop-es:ecnumber

114162

prop-es:geneatlasImage

PBB_GE_TH_208291_s_at_tn.png

prop-es:hgncid

11782

prop-es:homologene

307

prop-es:hsEnsembl

ENSG00000180176

prop-es:hsEntrezgene

7054

prop-es:hsGenlocChr

11

prop-es:hsGenlocDb

hg19

prop-es:hsGenlocEnd

2193107

prop-es:hsGenlocStart

2185159

prop-es:hsRefseqmrna

NM_000360

prop-es:hsRefseqprotein

NP_000351

prop-es:hsUniprot

P07101

prop-es:mmEnsembl

ENSMUSG00000000214

prop-es:mmEntrezgene

21823

prop-es:mmGenlocChr

7

prop-es:mmGenlocEnd

142931128

prop-es:mmGenlocStart

142892752

prop-es:mmRefseqmrna

NM_009377

prop-es:mmRefseqprotein

NP_033403

prop-es:mmUniprot

P24529

prop-es:name

Tirosina hidroxilasa

prop-es:número

6523 6114 6 7 1 2 3 15 10 20 22 16

prop-es:omim

191290

prop-es:pmc

336196 306135 48658

prop-es:pmid

2892893 2896667 8528210 6137760 2902075 7715703 2882428 7814018 2888085 1347949 6150037 2905129 2887169 2892528 2872999 12428766 7789962 1973163 33381

prop-es:publicación

Hum. Mol. Genet. J. Biochem. Nucleic Acids Res. Nature J. Neurochem. Biochem. Biophys. Res. Commun. Cytogenet. Cell Genet. Hum. Genet. Mol. Cell. Biochem. Mol. Neurobiol. J. Biol. Chem. Biochemistry Proc. Natl. Acad. Sci. U.S.A.

prop-es:páginas

11682 907 123 640 6910 1341 389 988 971 129 707 716 6733 4744 29 7406 1209 13680 2365

prop-es:símbolo

TH

prop-es:título

Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3. A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome. Tyrosine hydroxylase regulation in the central nervous system. ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types. Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene. Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs. Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. Recessively inherited L-DOPA-responsive dystonia caused by a point mutation in the tyrosine hydroxylase gene. Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Frequent sequence variant in the human tyrosine hydroxylase gene.

prop-es:variosPdb

,

prop-es:volumen

146 157 42 50 53 4 15 26 259 263 103 265 75 374 89 95 326

prop-es:width

230

prop-es:ecNumber

114162

dbo:wikiPageID

1240859

dbo:wikiPageRevisionID

130159170

dbo:wikiPageLength

11966

dbo:arm

p

dbo:band

15.5

dbo:chromosome

11

dbo:ecNumber

1.14.16.2

dbo:hgncid

11782

dbo:omim

191290

dbo:symbol

TH DYT14; DYT5b; TYH

prov:wasDerivedFrom

n15:0

dbo:abstract

La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​

Subject Item

wikipedia-es:Tirosina_hidroxilasa

foaf:primaryTopic

dbpedia-es:Tirosina_hidroxilasa