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About: Tirosina hidroxilasa

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La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​

Property Value
dbo:abstract
  • La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​ (es)
  • La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​ (es)
dbo:arm
  • p
dbo:band
  • 15.5
dbo:chromosome
  • 11
dbo:ecNumber
  • 1.14.16.2
dbo:hgncid
  • 11782
dbo:omim
  • 191290 (xsd:integer)
dbo:symbol
  • DYT14; DYT5b; TYH
  • TH
dbo:wikiPageID
  • 1240859 (xsd:integer)
dbo:wikiPageLength
  • 11966 (xsd:integer)
dbo:wikiPageRevisionID
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prop-es:altsymbols
  • DYT14; DYT5b; TYH (es)
  • DYT14; DYT5b; TYH (es)
prop-es:autor
  • Coker GT, Vinnedge L, O'Malley KL (es)
  • Craig SP, Buckle VJ, Lamouroux A, et al. (es)
  • Ginns EI, Rehavi M, Martin BM, et al. (es)
  • Grima B, Lamouroux A, Boni C, et al. (es)
  • Haycock JW (es)
  • Haycock JW, Ahn NG, Cobb MH, Krebs EG (es)
  • Joh TH, Park DH, Reis DJ (es)
  • Kaneda N, Kobayashi K, Ichinose H, et al. (es)
  • Knappskog PM, Flatmark T, Mallet J, et al. (es)
  • Kobayashi K, Kaneda N, Ichinose H, et al. (es)
  • Le Bourdellès B, Boularand S, Boni C, et al. (es)
  • Lüdecke B, Bartholomé K (es)
  • Lüdecke B, Dworniczak B, Bartholomé K (es)
  • Masserano JM, Weiner N (es)
  • Meloni R, Biguet NF, Mallet J (es)
  • O'Malley KL, Anhalt MJ, Martin BM, et al. (es)
  • Vulliet PR, Woodgett JR, Cohen P (es)
  • Zhou QY, Quaife CJ, Palmiter RD (es)
  • Coker GT, Vinnedge L, O'Malley KL (es)
  • Craig SP, Buckle VJ, Lamouroux A, et al. (es)
  • Ginns EI, Rehavi M, Martin BM, et al. (es)
  • Grima B, Lamouroux A, Boni C, et al. (es)
  • Haycock JW (es)
  • Haycock JW, Ahn NG, Cobb MH, Krebs EG (es)
  • Joh TH, Park DH, Reis DJ (es)
  • Kaneda N, Kobayashi K, Ichinose H, et al. (es)
  • Knappskog PM, Flatmark T, Mallet J, et al. (es)
  • Kobayashi K, Kaneda N, Ichinose H, et al. (es)
  • Le Bourdellès B, Boularand S, Boni C, et al. (es)
  • Lüdecke B, Bartholomé K (es)
  • Lüdecke B, Dworniczak B, Bartholomé K (es)
  • Masserano JM, Weiner N (es)
  • Meloni R, Biguet NF, Mallet J (es)
  • O'Malley KL, Anhalt MJ, Martin BM, et al. (es)
  • Vulliet PR, Woodgett JR, Cohen P (es)
  • Zhou QY, Quaife CJ, Palmiter RD (es)
prop-es:año
  • 1979 (xsd:integer)
  • 1983 (xsd:integer)
  • 1984 (xsd:integer)
  • 1986 (xsd:integer)
  • 1987 (xsd:integer)
  • 1988 (xsd:integer)
  • 1989 (xsd:integer)
  • 1990 (xsd:integer)
  • 1992 (xsd:integer)
  • 1995 (xsd:integer)
  • 1996 (xsd:integer)
  • 2002 (xsd:integer)
prop-es:banda
  • 155 (xsd:integer)
prop-es:brazo
  • p (es)
  • p (es)
prop-es:chembl
  • 1969 (xsd:integer)
prop-es:cromosoma
  • 11 (xsd:integer)
prop-es:doi
  • 101007 (xsd:integer)
  • 101016 (xsd:integer)
  • 101021 (xsd:integer)
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prop-es:ecNumber
  • 114162 (xsd:integer)
prop-es:ecnumber
  • 114162 (xsd:integer)
prop-es:geneatlasImage
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  • PBB_GE_TH_208291_s_at_tn.png (es)
prop-es:hgncid
  • 11782 (xsd:integer)
prop-es:homologene
  • 307 (xsd:integer)
prop-es:hsEnsembl
  • ENSG00000180176 (es)
  • ENSG00000180176 (es)
prop-es:hsEntrezgene
  • 7054 (xsd:integer)
prop-es:hsGenlocChr
  • 11 (xsd:integer)
prop-es:hsGenlocDb
  • hg19 (es)
  • hg19 (es)
prop-es:hsGenlocEnd
  • 2193107 (xsd:integer)
prop-es:hsGenlocStart
  • 2185159 (xsd:integer)
prop-es:hsRefseqmrna
  • NM_000360 (es)
  • NM_000360 (es)
prop-es:hsRefseqprotein
  • NP_000351 (es)
  • NP_000351 (es)
prop-es:hsUniprot
  • P07101 (es)
  • P07101 (es)
prop-es:mmEnsembl
  • ENSMUSG00000000214 (es)
  • ENSMUSG00000000214 (es)
prop-es:mmEntrezgene
  • 21823 (xsd:integer)
prop-es:mmGenlocChr
  • 7 (xsd:integer)
prop-es:mmGenlocEnd
  • 142931128 (xsd:integer)
prop-es:mmGenlocStart
  • 142892752 (xsd:integer)
prop-es:mmRefseqmrna
  • NM_009377 (es)
  • NM_009377 (es)
prop-es:mmRefseqprotein
  • NP_033403 (es)
  • NP_033403 (es)
prop-es:mmUniprot
  • P24529 (es)
  • P24529 (es)
prop-es:name
  • Tirosina hidroxilasa (es)
  • Tirosina hidroxilasa (es)
prop-es:número
  • 1 (xsd:integer)
  • 2 (xsd:integer)
  • 3 (xsd:integer)
  • 6 (xsd:integer)
  • 7 (xsd:integer)
  • 10 (xsd:integer)
  • 15 (xsd:integer)
  • 16 (xsd:integer)
  • 20 (xsd:integer)
  • 22 (xsd:integer)
  • 6114 (xsd:integer)
  • 6523 (xsd:integer)
prop-es:omim
  • 191290 (xsd:integer)
prop-es:pmc
  • 48658 (xsd:integer)
  • 306135 (xsd:integer)
  • 336196 (xsd:integer)
prop-es:pmid
  • 33381 (xsd:integer)
  • 1347949 (xsd:integer)
  • 1973163 (xsd:integer)
  • 2872999 (xsd:integer)
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  • 2902075 (xsd:integer)
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prop-es:publicación
  • J. Biol. Chem. (es)
  • Nature (es)
  • Biochem. Biophys. Res. Commun. (es)
  • Hum. Mol. Genet. (es)
  • Proc. Natl. Acad. Sci. U.S.A. (es)
  • Hum. Genet. (es)
  • Nucleic Acids Res. (es)
  • Biochemistry (es)
  • J. Neurochem. (es)
  • Cytogenet. Cell Genet. (es)
  • J. Biochem. (es)
  • Mol. Cell. Biochem. (es)
  • Mol. Neurobiol. (es)
  • J. Biol. Chem. (es)
  • Nature (es)
  • Biochem. Biophys. Res. Commun. (es)
  • Hum. Mol. Genet. (es)
  • Proc. Natl. Acad. Sci. U.S.A. (es)
  • Hum. Genet. (es)
  • Nucleic Acids Res. (es)
  • Biochemistry (es)
  • J. Neurochem. (es)
  • Cytogenet. Cell Genet. (es)
  • J. Biochem. (es)
  • Mol. Cell. Biochem. (es)
  • Mol. Neurobiol. (es)
prop-es:páginas
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prop-es:símbolo
  • TH (es)
  • TH (es)
prop-es:título
  • Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene. (es)
  • Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. (es)
  • Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. (es)
  • Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3. (es)
  • Frequent sequence variant in the human tyrosine hydroxylase gene. (es)
  • A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. (es)
  • Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. (es)
  • Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs. (es)
  • Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. (es)
  • Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. (es)
  • ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. (es)
  • Tyrosine hydroxylase regulation in the central nervous system. (es)
  • Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types. (es)
  • Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. (es)
  • Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. (es)
  • Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. (es)
  • A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome. (es)
  • Recessively inherited L-DOPA-responsive dystonia caused by a point mutation in the tyrosine hydroxylase gene. (es)
  • Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. (es)
  • Post-genomic era and gene discovery for psychiatric diseases: there is a new art of the trade? The example of the HUMTH01 microsatellite in the Tyrosine Hydroxylase gene. (es)
  • Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase. (es)
  • Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. (es)
  • Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3. (es)
  • Frequent sequence variant in the human tyrosine hydroxylase gene. (es)
  • A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics. (es)
  • Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. (es)
  • Isolation and characterization of the human tyrosine hydroxylase gene: identification of 5' alternative splice sites responsible for multiple mRNAs. (es)
  • Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector. (es)
  • Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. (es)
  • ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. (es)
  • Tyrosine hydroxylase regulation in the central nervous system. (es)
  • Characterization of rat and human tyrosine hydroxylase genes: functional expression of both promoters in neuronal and non-neuronal cell types. (es)
  • Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types. (es)
  • Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms. (es)
  • Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene. (es)
  • A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome. (es)
  • Recessively inherited L-DOPA-responsive dystonia caused by a point mutation in the tyrosine hydroxylase gene. (es)
  • Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation. (es)
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dct:subject
rdf:type
rdfs:comment
  • La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​ (es)
  • La tirosina hidroxilasa o tirosina 3-monooxigenasa (EC 1.14.16.2) es la enzima responsable de catalizar la conversión del aminoácido L-tirosina a dihidroxifenilalanina (DOPA). La DOPA es el precursor de la dopamina, que a su vez es también el precursor de la noradrenalina y la adrenalina. En humanos, la tirosina hidroxilasa es codificada por el gen TH.​ (es)
rdfs:label
  • Tirosina hidroxilasa (es)
  • Tirosina hidroxilasa (es)
owl:sameAs
prov:wasDerivedFrom
foaf:isPrimaryTopicOf
is dbo:wikiPageRedirects of
is owl:sameAs of
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