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Subject Item

dbpedia-es:SIRT1

rdf:type

wikidata:Q206229 owl:Thing wikidata:Q8054 dbo:Protein dbo:Biomolecule

rdfs:label

SIRT1

rdfs:comment

Sirtuina 1, también conocida como "sirtuína-1 desacetilasa dependiente de NAD", es una proteína codificada por el gen "SIRT1".​​ SIRT1 significa "sirtuína (homólogo 2 de regulación de información de tipo unión silente) 1 (S. cerevisiae), en referencia al hecho de que su homólogo (equivalente biológico a través de especies) en levadura (S. cerevisiae) es la Sir2. SIRT1 es una enzima desacetilasa que contribuye a la regulación celular (respuesta a estresores, longevidad y otros factores homeostáticos).​

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n14:02kffqd

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category-es:Genes_del_cromosoma_10 n16:1 category-es:Sirtuínas category-es:Proteínas_humanas

foaf:isPrimaryTopicOf

wikipedia-es:SIRT1

prop-es:altsymbols

SIR2L1

prop-es:autor

Howitz KT, Bitterman KJ, Cohen HY, et al. Deloukas P, Earthrowl ME, Grafham DV, et al. Brunet A, Sweeney LB, Sturgill JF, et al. Bitterman KJ, Anderson RM, Cohen HY, et al. van der Horst A, Tertoolen LG, de Vries-Smits LM, et al. Travers H, Spotswood HT, Moss PA, Turner BM Vaziri H, Dessain SK, Ng Eaton E, et al. Senawong T, Peterson VJ, Avram D, et al. Wiemann S, Weil B, Wellenreuther R, et al. Takata T, Ishikawa F Strausberg RL, Feingold EA, Grouse LH, et al. Picard F, Kurtev M, Chung N, et al. Frye RA Cohen HY, Miller C, Bitterman KJ, et al. Langley E, Pearson M, Faretta M, et al. Motta MC, Divecha N, Lemieux M, et al. Yeung F, Hoberg JE, Ramsey CS, et al. Luo J, Nikolaev AY, Imai S, et al. Ota T, Suzuki Y, Nishikawa T, et al.

prop-es:año

1999 2002 2003 2000 2001 2004

prop-es:banda

2231

prop-es:brazo

q

prop-es:caption

280

prop-es:cromosoma

10

prop-es:doi

101093 101126 101101 101016 101006 101038 101074 101073

prop-es:entrezgene

23411

prop-es:hgncid

4881

prop-es:name

"sirtuína 1

prop-es:número

6990 6993 44 5666 47 5682 12 10 4 1 2 3 28 26 6954

prop-es:pmc

139241 2819354 126010 423286 2820247 311072

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12477932 10381378 15205477 15164054 12006491 10873683 11672522 11672523 12535671 15175761 15126506 15152190 14702039 14980222 12930829 12297502 11230166 12939617 14976264 12413881

prop-es:publicación

Exp. Cell Res. EMBO J. Cell Biochem. Biophys. Res. Commun. Nat. Genet. Science Genome Res. J. Biol. Chem. Nature Proc. Natl. Acad. Sci. U.S.A.

prop-es:páginas

2011 45099 375 273 2383 2369 793 16899 40 771 250 551 390 149 137 422 191 43041 28873

prop-es:símbolo

SIRT1

prop-es:título

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Complete sequencing and characterization of 21,243 full-length human cDNAs. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Negative control of p53 by Sir2alpha promotes cell survival under stress. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. hSIR2 functions as an NAD-dependent p53 deacetylase. Human CD34+ hematopoietic progenitor cells hyperacetylate core histones in response to sodium butyrate, but not trichostatin A. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2. The DNA sequence and comparative analysis of human chromosome 10. Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins metabolize NAD and may have protein ADP-ribosyltransferase activity. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Mammalian SIRT1 represses forkhead transcription factors. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor -interacting protein 2-mediated transcriptional repression.

prop-es:volumen

303 11 301 305 23 21 260 280 273 278 279 277 425 429 107 99 116 36

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4109674

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120416900

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18616

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22.31

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10

dbo:entrezgene

23411

dbo:hgncid

4881

dbo:symbol

SIRT1 SIR2L1

prov:wasDerivedFrom

n12:0

dbo:abstract

Sirtuina 1, también conocida como "sirtuína-1 desacetilasa dependiente de NAD", es una proteína codificada por el gen "SIRT1".​​ SIRT1 significa "sirtuína (homólogo 2 de regulación de información de tipo unión silente) 1 (S. cerevisiae), en referencia al hecho de que su homólogo (equivalente biológico a través de especies) en levadura (S. cerevisiae) es la Sir2. SIRT1 es una enzima desacetilasa que contribuye a la regulación celular (respuesta a estresores, longevidad y otros factores homeostáticos).​

Subject Item

dbpedia-es:Sirtuina_1

dbo:wikiPageRedirects

dbpedia-es:SIRT1

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dbpedia-es:Sirtuína_1

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dbpedia-es:SIRT1

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wikipedia-es:SIRT1

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dbpedia-es:SIRT1

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dbr:Sirtuin_1

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dbpedia-es:SIRT1